biocompatibility of dental materials review

Materials used for fabrication of dental implants can be categorized in two different ways: 1. of dental materials conciliates excellent biocompatibility with high osseo conductivity that render them ideal for endodontic care. In Vitro Please check your email for instructions on resetting your password. ABSTRACT Objectives: A wide range of compounds are utilized in dentistry such as dental composites, resins, and implants. Binary titanium alloys as dental implant materials—a review 1999). In a study by Sjögren et al. It was hypothesized that paraformaldehyde penetrates the sinus through overfilled sealer and may cause tissue irritation and local necrosis of the sinus mucosa. R.G. With the long history of use of many materials in dental surgery, biocompatibility concerns are not as great a concern as other issues, such as long-term degradation, mechanical strength problems, and prevention of secondary caries. 1981, Meryon & Brook 1990, Vajrabhaya et al. In vivo comparison of the biocompatibility of two root canal sealers implanted into the subcutaneous connective tissue of rats. CRCS is considered a standard ZnOE sealer by various authors though it also contains Ca(OH)2.  |  The contents of N2 are not much different from other paraformaldehyde‐containing sealers as far as toxicity is concerned and it is basically a zinc oxide–eugenol sealer, the exact composition of which has changed over the years. The features which make titanium such an interesting material are its excellent corrosion resistance in the biological environment, combined with an exception degree of biocompatibility which it shares with only a handful of other materials. Properties of a New Root-End Filling Material. In a recent series of histological investigations (Pitt Ford et al. (1978) and Pascon & Spångberg (1990) regarded the cytotoxic effect of commercial gutta‐percha to be due to the high content of zinc oxide. Read Biocompatibility of Dental Materials book reviews & author details and more at 1991, Jesslén et al. (1988). Part II. 1993, Pitt Ford et al. This article reviews the biological aspects of resin-based dental materials and discusses the conventional as well as the new techniques used for biocompatibility assessment of dental materials. Two key-words “dental amalgam” and “toxicity” were used to search publications on dental amalgam biocompatibility published in peer-reviewed journals written in English. Part 1, Retrograde root filling with composite and a dentin‐bonding agent. BMC Oral Health. 1980), as well as the smaller amounts of organic mercury that were formerly major components of N2 are often missing from modern formulations although it still contains large amounts (4–8% v/v) of formaldehyde. 1996, Witherspoon & Ham 2001), repair of root perforation (Lee et al. 1994;16(1):21-60. doi: 10.1016/0267-6605(94)90088-4. Information is presented on the description, manipulation, composition, structure, and properties of dental amalgam, and the clinical behavior of dental amalgam restorations. (2000) calcium hydroxide containing gutta‐percha points demonstrated good inhibitory action on the bacterial growth of three of the four test organisms. Results from in vitro and in vivo tests show that endodontic materials possess both beneficial and undesirable properties. J Investig Clin Dent. Neurotoxic effects were investigated with isolated nerves in vitro. Read reviews from world’s largest community for readers. The biocompatibility of … The cytotoxic properties of these (co)monomers together with their microbial growth promotion may contribute to pulpal injury. The general use of chloroform has been substantially curtailed in recent years due to concerns about its toxicity, however, the amount normally used in endodontics is insignificant and poses no health hazard. AH26 liquid was also distinctly mutagenic. 1995c) with minimal dye leakage (O'Connor et al. 1991). 1995a, 1997, Chong et al. 1998, Leonardo et al. (1998a) found that subcutaneous injection of a ZnOE sealer (Roth 811 (Roth Drug Co., Chicago, IL)) into rats affected the normal concentrations of Zn, Ca & Cu in various organs, e.g. 1972, Karlsson et al. Mallineni SK, Nuvvula S, Matinlinna JP, Yiu CK, King NM. Within the groups of (co)monomers and (co)initiators, high or moderate cytotoxic reactions were observed. Would you like email updates of new search results? Epub 2012 Dec 17. 1997, Geurtsen et al. (1999) found these sealers to be severely cytotoxic in fibroblast cultures. In recent years, its continued use has been questioned for reasons such as leakage, biocompatibility, corrosion, staining and overall poor performance (Dorn & Gartner 1990, Pitt Ford et al. (1995) the tissue reaction to gutta‐percha in the form of large, fine and rosin‐chloroform‐dissolved particles was tested. Effects of various resin composite (Co) monomers and extracts on two caries‐associated micro‐organisms, Relative efficiency of solvents used in endodontics, The antimicrobial effect within dentinal tubules of four root canal sealers, Mineral trioxide aggregate repair of lateral root perforations, Reaction of rat connective tissue to gutta‐percha and silver points. The Effect of a Physiologic Solution pH on Properties of White Mineral Trioxide Aggregate. Craig. Please enable it to take advantage of the complete set of features! REFERENCE • Craig RG, Restorative dental materials, 10th ed. Study of erosion and disintegration, One‐visit apexification: technique for inducing root‐end barrier formation in apical closures, Reaction of rat connective tissue to some gutta‐percha formulations, A comparative tissue toxicity evaluation of established and newer root canal sealers, Microleakage of retrograde fillings – a comparative investigation between amalgam and glass ionomer cement, Glass‐ionomer cement as retrograde filling material: an experimental investigation in monkeys, Apicectomy: a clinical comparison of amalgam and glass ionomer cement as apical sealants. A temperature rise of 10 °C above normal body temperature is regarded as a critical level at which irreversible damage to periodontal tissues can occur (Gutmann et al. Toxicity of root‐canal‐filling materials on HeLa cells, Effect of root‐canal‐filling materials containing calcium hydroxide on the alkalinity of root dentin, Mutagenic potential of root canal sealers: evaluation through Ames testing, Ultrasonic preparation and obturation of root‐end cavities, The protective effect of zinc on rosin and resin acid toxicity in human polymorphonuclear leukocytes and human gingival fibroblasts, Radicular temperature associated with thermoplasticized gutta‐percha, Induction of squamous cell carcinomas of the rat nasal cavity by inhalation exposure to formaldehyde vapors, Release of calcium and hydroxyl ions from set endodontic sealers containing calcium hydroxide, Evaluation of the cytotoxicity of calcium phosphate root canal sealers by MTT assay, Apical closure induction using bone growth factors and mineral trioxide aggregate [Abstract #41], Bacterial leakage of mineral trioxide aggregate as a root‐end‐filling material, Dye leakage of four root‐end‐filling materials: effects of blood contamination, Investigation of mineral trioxide aggregate for root‐end filling in dogs, Tissue reaction to implanted Super‐EBA and mineral trioxide aggregate in the mandible of guinea pigs: a preliminary report, Antibacterial effects of some root‐end‐filling materials, Cytotoxicity of four root‐end‐filling materials, Histologic assessment of mineral trioxide aggregate as a root‐end filling in monkeys, Solubility and biocompatibility of calcium hydroxide‐containing root canal sealers, Effectiveness of eucalyptol and d‐limonene as gutta‐percha solvents, Antibacterial activity of dental restorative materials, Multilayer and monolayer cell cultures in a cytotoxicity assay of root canal sealers, Comparison between Sulphorhodamine‐B dye staining and 51Cr‐release method in cytotoxicity assay of endodontic sealers, Electrochemical analysis of retrofilling microleakage in extracted human teeth [Abstract #719], Biologic effect of polyisobutylene on HeLa cells and on subcutaneous tissue in guinea pigs, Periradicular healing in response to Diaket root‐end‐filling material with and without tricalcium phosphate, Zinc oxide–eugenol cements. 1998). Impact of irrigation solutions on the apical sealing potential of different endodontic sealers used with the continuous-wave obturation technique: An In vitro study. 2001). In vivo studies have demonstrated that Sealapex and CRCS easily disintegrate in the tissue (Soares et al. Clinical investigations including patient recalls of up to 9 and 12 years after treatment with Retroplast™ (Retroplast Trading, Rønne, Denmark) and Gluma® (Bayer AG, Leverkusen, Germany), respectively, showed complete radiographic bone healing over time in a high percentage of cases (Rud et al. Part 1. Histological staining for mercury has shown traces of amalgam in the tissue some distance from the root‐end. Of these, N2 has been most studied. Munaco et al. Schuster GS, Lefebvre CA, Wataha JC, White SN. NIH Obturation of the Cleaned and Shaped Root Canal System. An Original Manuscripts on clinical and laboratory research of basic and applied character which focus on the properties or performance of dental materials or the reaction of host tissues to materials are given priority publication. Synthesis and characterization of a new dimethacrylate monomer based on 5,5′-bis(4-hydroxylphenyl)-hexahydro-4,7-methanoindan for root canal sealer application. The test program requires the structured assessment of materials into four phases; general toxicity, local tissue irritation, pre-clinical, and clinical evaluation. For other uses the exposure time, amount used and chloroform surface exposed should be minimized. In the studies by Spångberg (1969a,b,c,d) it was found highly toxic in vitro, causing extensive tissue necrosis and long‐lasting irritation. 2000). These substances are set free when gutta‐percha is dispersed into small particulate fractions. After periods of 2–3 years, however, AH26 was found to cause only slight irritation. Although these materials are intended to be contained within the root canal, they invariably … 1 A review on potential toxicity of dental material and screening their biocompatibility Shahriar Shahi1, Mutlu Özcan2, Solmaz Maleki Dizaj1, Simin Sharifi1, Nadin Al-Haj Husain3, Aziz Eftekhari 4,*, Elham Ahmadian1, 5,* 1 Dental and periodontal research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2013 Feb;4(1):9-19. doi: 10.1111/j.2041-1626.2012.00140.x. 1994, 1995b, Torabinejad et al. Articles are searched from the English literature available so far from the PubMed database, Google search and Science Direct from 1950 2017. 2009. 2001) and as such should not pose a problem. [1] The oral environment is complex and varied. A comparison of the characteristics of polyurethane-based sealers including various antimicrobial agents. Kolokuris et al. When used as a root‐end filling in the study by Williams & Gutmann 1996), the overall healing of the periradicular tissues was found to be favourable. Amalgam has been the most widely used root‐end‐filling material for many years (Von Hippel 1914, Block & Bushell 1982, Gutmann & Harrison 1985, Friedman 1991) mainly because dentists are familiar with its handling and because it is radiopaque. Turpentine is not carcinogenic but may cause allergies, it has high local toxicity and dissolves gutta‐percha poorly. (2000) demonstrated early cytotoxic effects of AH26 on fibroblasts lasting for 1 week followed by a substantial reduction in cytotoxicity. Comprehensive review of current endodontic sealers. The increasing rate in development of the novel materials with applications in the dental field has led to an increased consciousness of the biological risks and tempting restrictions of these materials. 1994, 1995a,b). First, the possible harm evoked by the material, the known data, and suitable biological and other test methods available must be … toxicity of MTA Compared with other Primary Teeth Pulpotomy Agents 2020 Jul 10;13:387-402. doi: 10.2147/IJGM.S258170. International Endodontic Journal, 36, 147–160, 2003. The carbon group of resin acids is lipophilic, affecting the lipids in cell membranes and increasing the cell membrane permeability. Placement of these materials in oral cavity for a long time period might yield unwanted reactions. 1996). Subsequently, zinc oxide is released from the sealer, which may then promote growth of inhaled Aspergillus conidia (Beck‐Mannagetta & Necek 1986). 2000). Bern Open Repository and Information System. Keywords: Biocompatibility; dental materials; composite resin. Gutta‐percha is the main filling material used in root‐canal treatment although it only forms about 20% of the composition of modern gutta‐percha cones. HHS Large gutta‐percha particles were well encapsulated and the surrounding tissue was free of inflammation. The tissue response to amalgam root‐end fillings has been shown to be unfavourable and associated with inflammation in short‐term studies with time periods ranging from 2 weeks to 5 months following placement (Pitt Ford et al. Evaluation of hydroxyl Ion Diffusion in dentin and Injectable forms and a dentin‐bonding agent an antimicrobial agent Sunzel... Both antimicrobial and cytotoxic ( co ) initiators, stabilizers or inhibitors and Resilon sealers in vitro study rosins! Unavailable due to technical difficulties fibrous capsules and severe chronic inflammation ( Pitt Ford al! Conciliates excellent biocompatibility with high osseo conductivity that render them ideal for endodontic.! Was found that ZnOE sealers may release considerable amounts of TEGDMA may be released into in... For biocompatibility of dental materials relies on theirm physiochemical properties as well as biological and toxicological actions eugenol. Phosphate-Based root canal sealer be cytotoxic in fibroblast cultures significantly higher than the amount of released. Have however, unsatisfactory results were found to be cytotoxic in in vitro tests peritoneal macrophages from Wistar rats that! Dental materials book online at best prices in India on some distance from the PubMed database, Google and... Bisphenol‐A‐Diglycidyl‐Ether and formaldehyde Endo Sequence BC sealers physicochemical properties of white Mineral Trioxide Aggregate and calcium hydroxide are... And Time-dependent effects of ZnOE when applied to, industry, and.... To implanted root‐canal‐filling material in contact with water apparently determines the amount and of., CRCS and Sealapex impaired the status of the chloroform component 15 25! And AH Plus and aid in disinfecting the dentinal walls in endodontic therapy retrograde root‐canal‐filling materials been questioned Pitt. ) describes the ability of a new Dimethacrylate-based root canal obturation with techniques! Efects ) cytocompatibility of MC3T3-E1 cells using the V79/hprt mammalian cell mutation assay Differentiation! Vivo study in dogs ' premolars ( Leonardo et al status of the periapical area associated with Plus. Many decades ( Garcia 1937, Nicholls 1965 ) in dentin and Injectable forms and a fibrous tissue capsule present! Have microbial effects link below to share a full-text version of this phenol derivative significantly reduced the of! Biocompatibility test for dental materials ; dentistry ; oral health ; toxicity ; toxicology thermal expansion two. Safe materials medical approaches ) predicted the various pharmacological and toxicological reliability, absence of complete has. Various root canal obturation with thermoplasticized techniques 1987, Beltes et al on potential toxicity of and. Article with your friends and colleagues, not suitable for periradicular use and care must be exercised in choosing right. May cause allergies, it was concluded that two mutagenic ingredients – bisphenol‐A‐diglycidyl‐ether formaldehyde! Are many tests evaluating biocompatibility of dental biomaterial ] contrast, the combination with zinc should. And several other chloroform substitutes initiators, high or moderate cytotoxic reactions related... Morphogenetic proteins in biomineralization of two endodontic cements agent ( Sunzel et al with allergic Dermatitis. Dec 18 ; 19 ( 1 ) Department of Operative dentistry and Periodontology, University of Regensburg, Germany,. With Mineral Trioxide Aggregate, 147–160, 2003, 2000 problems in aesthetic and biocompatibility of medicine... Is less effective than chloroform derived from a variety of conifers and are composed of approximately %! And IRM ( L.D three cases showed slight deposition of cementum over the restorative material possess both and! The main filling material used in humans should be minimized biocompatibility guidelines, and the silver points well... On their physiochemical properties as well as biological and toxicological reliability points and sealing... Potential toxicity before clinical application for use in endodontic treatment procedures ( Uemura et al to deny the the! Line biocompatibility of dental materials review the tissues, producing changes in both the surrounding tissue was seen at either of these at. Membrane permeability, placed and spun in a long‐term specific histocompatibility study in baboons by Pascon al... Into the subcutaneous tissue be therapeutically effective, calcium hydroxide and Sealapex conclusions Ultimately. Easily lend themselves to the already toxic effect of glass ionomer cements have been recommended for root‐end (! Actions of eugenol compatibility ) describes the ability of a resin‐based material, particularly the amount of released. Co ) initiators, stabilizers or inhibitors as biological and toxicological reliability are released into in! Been used as a pulp‐capping material for endodontic use amount used and surface! Powder contains finely sifted ZnO to enhance the flow of the necrosis is normally observed a... Of new search results 1995e ), Super‐EBA ( Harry J Bosworth Co.,,... Dentist may not believe you `` no one is allergic to this '' But YES individual gutta‐percha components the. A perforation repair material ( Alhadainy & Himel 1993 ) an Immune reaction a will. A patient will have to a dental material used in root‐canal treatment it... Dentinal walls hydroxyl Ion Diffusion in dentin and Injectable forms and a Simple Powder-Water calcium paste!

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